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Polarimeter Selection Guide and Overview

Polarimeters for Chemical, Sugar, Pharmaceutical, Food, Beverage, University Laboratories

Product Category: Polarimeters

Industry: Food, Dairy and Wine, General Laboratory, Pharmaceutical, Personal Care and Natural Products

Supplier: Rudolph Research Analytical

Description

Polarimeter Model Selection Guide

Polarimeter models from Rudolph Research for chemical, sugar, pharmaceutical, cosmetics, essential oils, education, and university laboratories.

AUTOPOL VI Automatic Polarimeter

The AUTOPOL VI Automatic Polarimeter is Rudolph’s top of the line six wavelength polarimeter specifically designed for the most demanding analytical laboratories. The built in Ethernet port allows saving data directly to your network server and printing to a network printer. The USB ports allow printing to a printer that has Windows® drivers. This unit comes standard with six wavelengths, TempTrol™ NIST traceable standard, TempTrol™ sample cell, TempTrol™ temperature validation cell and IQOQ (Installation Quality, Operation Quality) documentation. AUTOPOL VI Polarimeter.

  • 0.0003 accuracy for low rotation samples of ±1° Arc
  • Ethernet port for network connection
  • Save measurements direct to your network/server
  • 3 USB ports
  • Connect to Windows® based printer via USB
  • 21CFR Part 11 Compliant
  • TempTrol™ Electronic Heating and Cooling
  • Six Standard Wavelengths
  • Designed for demanding analytical laboratories.

AUTOPOL V PLUS Automatic Polarimeter

The AUTOPOL V PLUS Automatic Polarimeter is Rudolph’s top of the line six wavelength instrument specifically designed with the input of the world’s largest pharmaceutical companies. This unit comes standard with 21CFR11 software and Rudolph’s Patented TempTrol™ System, which electronically heats and cools the sample to a specified temperature without the use of water circulation.This unit includes all wavelengths necessary to measure 99% of all monographs found in the USP, EP, JP and BP. IQOQ (Installation Quality Operation Quality) documentation is included with the instrument.

  • 6m HCl acid resistance: Silco Steel coating on the chamber temperature transfer surface and a Hastelloy measurement cell with NIST certificate certifying optical path length.
  • Comes with a NIST traceable quartz plate with three rotations: +0.998° Arc, +10.998° Arc, -10.000° Arc. Each rotation has a NIST certificate.
  • Intuitive Windows® based navigation architecture
  • 3 USB ports
  • Connect to Windows® based printer via USB
  • Ethernet port for network cable connection
  • Internet access allowing connection to Rudolph’s service department for remote testing and diagnostics
  • Save measurement data to your network/server
  • TempTrol™ Electronic Heating and Cooling
  • Six Standard Wavelengths

AUTOPOL V Automatic Polarimeter

The AUTOPOL V Automatic Polarimeter is designed for today’s FDA regulated analytical laboratories. Whether you are a Pharmaceutical, Nutraceutical or University Lab, the AUTOPOL V has the standard measurement and compliance features you must have, including:

  • 21CFR Part 11 Compliant
  • Temptrol™ Electronic Heating and Cooling
  • Six standard wavelengths
  • Touch panel user interface
  • Designed for use in FDA regulated Pharmaceutical, Nutraceutical and cGMP/GLP laboratories

AUTOPOL IV Automatic Polarimeter

The AUTOPOL IV Automatic Polarimeter is available in one, two and six wavelength versions and has a more expensive optical system than the Autopol III. It is the system of choice for research universities, pharmaceutical and fine chemical research departments. This instrument is also excellent for studying recimics and kinetics. Temperature control is accomplished using the patented Rudolph TempTrol™ system. IQOQ documentation is included with the instrument.

  • Measures Optical Rotation, Specific Rotation, Concentration, and User Defined Scales
  • Temptrol™ Electronic Heating and Cooling
  • 1, 2 and 6 wavelength models
  • Temperature Correction
  • Real-time clock
  • Print-out format control
  • Designed for use in Pharmaceutical, University, Essential Oil, and related industries.

AUTOPOL III Automatic Polarimeter

Polarimeter AP III - Rudolph Research

The AUTOPOL III Automatic Polarimeter is Rudolph’s entry-level pharmaceutical and research grade instrument  which has a ±0.002 Degrees Optical Rotation accuracy for rotations up to 1° Arc. This polarimeter comes standard with two wavelengths: 589nm and 546nm and will pass an FDA inspection with the appropriate water bath to control temperature. IQOQ documentation is included with the instrument.

  • Measures Optical Rotation, Specific Rotation, Concentration, and °Z (ISS) Sugar Degrees
  • Resolution: 0.001° Arc Optical Rotation
  • Accuracy: 0.002° Arc up to 1°, 0.2% above 1°
  • Simple touch panel user interface
  • Built in temperature probe
  • 8 inch Color Display, 800 x 600 pixel resolution with 400 nits of brightness
  • Data storage – 8 GB Non-removable Compact Flash
  • Optional Wavelengths 365nm, 405nm, 436nm, 578nm
  • 3- USB Ports, 2- RS232 serial ports, Ethernet Port for Network Communication
  • Entry level dual wavelength Pharmaceutical and Research grade instrument.

Choosing a Polarimeter for Pharmaceutical Laboratories

Below is an example of why Polarimeters with accuracy of ±0.02 and ±0.01 accuracy polarimeters are not suitable for pharmaceutical applications. Please review the USP monograph for the material Ofloxacin. Ofloxacin must have a specific rotation between +1° and -1° at a concentration of 10mg per ml. Biots Law:

The Autopol I has an accuracy of ±0.02° optical rotation. Below is how its relative accuracy affects a hypothetical Ofloxacin sample:

You cannot successfully inspect a pharmaceutical (such as Ofloxacin) having a Specific Rotation between+1 and ±1 and a 1% concentration, which is quite common for most pharmaceuticals, with an instrument that has an accuracy of ±2.0 in Specific Rotation.

The Autopol IV has an accuracy of 0.002 for Optical Rotations of 1°Arc for a total unknown of +/-0.002 under the same conditions:

AUTOPOL II Automatic Polarimeter

Polarimeter, Autopol II

The AUTOPOL II Automatic Polarimeter is a general-purpose polarimeter with ±0.01 Degrees Optical Rotation accuracy. This accuracy is applicable for food, university education, many chemical, flavor and fragrance applications, as well as pharmaceutical inspection in some countries. We strongly recommend against using this instrument for USP, EP, JP and BP pharmaceutical applications. Although IQOQ documentation is provided, Rudolph will not perform on-site IQOQ for pharmaceutical applications where a certificate of analysis will be issued. Click here to see the application note on Accuracy of a Polarimeter for Pharmaceutical Applications for clarification.

  • Measures Optical Rotation, Specific Rotation, Concentration, and °Z (ISS) Sugar Degrees
  • Resolution: 0.01° Arc Optical Rotation
  • Accuracy: 0.01° Arc Optical Rotation, 0.03°Z (ISS) Sugar Degrees
  • Simple touch panel user interface
  • Built in temperature probe
  • 8 inch Color Display, 800 x 600 pixel resolution with 400 nits of brightness
  • Data storage – 8 GB Non-removable Compact Flash
  • Optional Wavelengths 365nm, 405nm, 436nm, 578nm, 633nm
  • 3- USB Ports, 2- RS232 serial ports, Ethernet Port for Network Communication
  • Designed as a general purpose dual wavelength Automatic Polarimeter for budget focused Contract Laboratories, Food Laboratories and College Chemistry Laboratories.

AUTOPOL I Automatic Polarimeter

Polarimeter, AP I

The AUTOPOL I Automatic Polarimeter is Rudolph’s entry-level model with an accuracy of ±0.02 Degrees Optical Rotation. This accuracy is fine for food and educational applications where budget is critical but state of the art quality is still important. The Autopol I is not a pharmaceutical grade polarimeter and does not come with IQOQ documentation.

  • Measures Optical Rotation, Specific Rotation, Concentration, and °Z (ISS) Sugar Degrees
  • Resolution: 0.01° Arc Optical Rotation
  • Accuracy: 0.02° Arc Optical Rotation, 0.03°Z (ISS) Sugar Degrees
  • Simple touch panel user interface
  • Built in temperature probe
  • 8 inch Color Display, 800 x 600 pixel resolution with 400 nits of brightness
  • Data storage – 8 GB Non-removable Compact Flash
  • Built in temperature probe
  • 3 USB Ports, 2 RS232 & Ethernet Port for Network Connection
  • Designed as a single wavelength instrument for Food, Education and less demanding applications where budget is critical, but quality is still important.

Used Polarimeters – Factory Refurbished

Used refurbished Polarimeters

  • High Quality with a lower cost
  • Factory rebuilt and re-calibrated
  • 2 year warranties
  • Great for low volume labs, Universities, or where cost is a critical factor

Polarimeters for Chemical, Sugar, Pharmaceutical, Food, Beverage, University Laboratories

Whitepapers

Polarimetry – Optical Rotation vs. Specific Rotation

Polarimetry – Optical Rotation vs. Specific Rotation – What’s the Difference? By Angelo DePalma, PHD Polarimetry using Polarimeters measure the degree of rotation of polarized light as it passes through an optically active material. Polarimetry was discovered by Étienne-Louis Malus, a French engineer who was studying reflective glass. Several years later another Frenchman, Jean-Baptiste Biot,

Optical Rotation – Specific Rotation Measurement Procedures – Rudolph Research Polarimeter

Source Video: Polarimeter Measurement Procedures to Determine Optical Rotation / Specific Rotation Video Transcript from the Rudolph Research Video Library This video covers how to fill cells and make a (Optical Rotation and Specific Rotation) measurements using a Rudolph polarimeter equipped with the exclusive and patented Temptrol heating and cooling system. Although this demonstration was

Polarimeter Cell Cleaning Prior to Making a Measurement

Cleaning a Polarimeter Sample Cell – Video Transcript Video location: Polarimeter Sample Cell Cleaning Procedures This video gives a brief overview of the proper method of cleaning a Rudolph polarimeter cell. This video is relevant to; 40T Temptrol polarimeter cell supplied with the Autopol IV-T, V, V plus and VI – 40T Polarimeter cell is

Testimonials

Automatic Refractometer & Polarimeter Testimonial I.P. Callison & Sons

Incorporating this system into our laboratory has been like adding another employee. It saves time while ensuring accurate results, and is extremely user-friendly. In addition, I’ve found that Rudolph Research Analytical goes the extra mile to ensure their customer is satisfied with their product and their service. I would highly recommend this equipment and this company to any lab as busy as ours…

Automatic Polarimeter Testimonial Harvard University Medical School

…I have been extremely pleased with the Autopol (Polarimeter) instruments over the years…As expected, our refurbished Autopol II has been reliable and easy to use. I should add that your personal visit to help us set up the instrument was very helpful and illustrated to me that Rudolph Research stands behind its products.

Automatic Digital Polarimeter Testimonial Wyeth-Ayerst

Overall, the instrument has been trouble-free and easy to use. Combined with the excellent costumer service provided to me by Rudolph Research on every occasion I have contacted them, I highly recommend the instrument…

Digital Automatic Polarimeter University of Mississippi – 2nd Testimonial

…we have been extremely pleased with the performance of this instrument, in terms of sensitivity and reproducibility. The instrument is very robust, and the stainless steel jacketed cells are truly a bonus, unlike the old glass cells, these are very user friendly and forgiving, especially when handled by clumsy graduate students!

Digital Polarimeter Testimonial Ann Arbor Labs

…after evaluating various polarimeters from well-known manufacturers, we ended buying one from Rudolph Research…This letter is to confirm that we are very pleased doing business with your company.

Digital Polarimeter Testimonial Solutec America

I have used numerous polarimeters and this is by far the best. We have had it for 1 ½ years and have had zero problems; the original lamp is still in the instrument. I recommend it over other instruments…we have had no problems. It is one piece of equipment that you never worry about.”

Digital Polarimeter Testimonial Sigma-Aldrich

The Autopol V (Polarimeter) has performed very well throughout the entire five years…. We are very happy with our Autopol and would recommend one to any lab considering a purchase of an automated polarimeter…

Scientific Solutions

Scientific Solutions have been providing carefully selected laboratory and analytical equipment to Australian Industries such as Environmental, Pharmaceutical, Food and Beverage and Research markets of the Science Industry for over a decade.

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