02 9543 7377


 Linear, Automated Parallel Synthesis Platform

Product Category: Chemical Synthesis and Crystallisation

Industry: Catalysis Chemical Synthesis and Crystallisation

Supplier: H.E.L. Group


The AutoMATE is a highly versatile, linear, automated parallel synthesis platform, for use in general chemical synthesis within R&D and process development, as well as more bespoke applications.  As with the PolyBLOCK, the independently controlled reaction zones make AutoMATE especially well-suited for DoE campaigns and the platform’s modular design allows for an easy expansion of capabilities.  In particular, the linear reactor design of the AutoMATE makes it ideal for more demanding applications, such as where multiple inputs and outputs are required.

Application modules that can be added include:

  • Solubility/crystallization monitoring
  • Online calorimetry option
  • Catalyst screening

The platform supports reactor volumes of up to 500 ml per reactor and is equipped with adaptors to support a range of reactor types and sizes, including integration with H.E.L’s catalyst screening CAT reactor blocks.  Additional functionality modules include:

  • Liquid dosing
  • Gas feed
  • Liquid sampling, including integration with the ASU
  • Quick-connect refluxing option
  • Quick-connect inerting solution
  • pH monitoring

Chemical Synthesis Specifications

Chemical Synthesis Brochure

Features and Options

Temperature Control

  • Ambient to 250 ⁰C (without external cooling).
  • Options to increase the range of -40 ⁰C (circulator dependent) or up to 350 ⁰C.
  • A separate mantle around each reactor allows the temperature to be controlled individually.
  • With a range/difference of over 100 °C between the reactors.

Independent Stirring

  • Indirect agitation with suspended magnetic stirring as standard.
  • Suspended agitation for efficient mixing on small-scale and non-viscous samples.
  • The more spacious ‘suspended’ stirrers are suitable for slurries.
  • Optional Overhead direct agitation for larger vessels.

Intelligent Software Control and Analysis

  • Control software enables regular data logging, multi-step recipes, parameter control, and feedback loops.

Safety Features

  • Include automatic user-configurable reaction detection and shutdown procedures, to ensure user safety.
  • Automatic hardware and software fail-safes are installed on every system.

Condenser options

  • Easy quick-connect solution for condensing and inerting in larger reactors. Seals allow condensers to be removed without cooling liquid spillage.
  • Also available reflux and inerting block, with adapters for vials, tubes, and reactors


Reactor Options

  • Vessel types are available in Glass, Stainless Steel, or Hastelloy. With reactor volumes up to 500 ml
  • High Pressure and Vacuum Systems available, more details on our high-pressure system can be found on the high-pressure variant
  • Sampling Systems through active pumps, manual dip tubes, automated level control, or multisampling units, like the ASU
  • Reagent Addition through the fully automated liquid and gas feeds as well as volumetric syringe pumps. These solutions can be applied to both high and low-pressure systems.
  • Control Options all relevant inputs can be logged, enabling automated monitoring and, where appropriate, feedback control of the reactor system
  • Sensor Options
    • Temperature, pressure, pH, turbidity, conductivity
    • Integration of third-party probes is possible, such as in-situ FTIR, particle sizing probes, and Raman probes.


The following are a list of some technical publications which highlight the use of the equipment.

Understanding the agglomerate crystallisation of hexamine through X-ray microscopy and crystallographic modelling
Thai T.H. Nguyen, Parmesh Gajjar, Jun Sun, Robert B. Hammond, Darragh Murnane, Benjamin Tordoff, Erik Lauridsen, Philip J. Withers and Kevin J. Roberts

01-Feb-2023 or purchase maybe required for full access)

Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole
Jacob R. Hauser1,2, Hester A. Beard1,2, Mary E. Bayana1,3, Katherine E. Jolley1,3, Stuart L. Warriner1,2 and Robin S. Bon*2,4

01-Sep-2021 or purchase maybe required for full access)

Concentration and Separation of Heavy Rare-Earth Metals at Stripping Stage
Olga Cheremisina, Vasiliy Sergeev , Alexander Fedorov * and Daria Alferova

01-Dec-2019 or purchase maybe required for full access)

Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors
A. John Blacker and Katherine E. Jolley

01-Dec-2015 or purchase maybe required for full access)

Comprehensive kinetic model for the dissolution, reaction, and crystallization processes involved in the synthesis of aspirin
David E. Joiner, Julien Billeter, Mary Ellen P. McNally, Ron M. Hoffman and Paul J. Gemperline

01-Feb-2014 or purchase maybe required for full access)

Rheological and Hydrogenation Study using a Flow Modified Sponge Ni Catalyst
J. Matt Farmer1*, Norman Marin-Astorga1, Bruce Lacey1, Steve McMahon1, and Chandresh Malde2

01-Jul-2013 or purchase maybe required for full access)

Mixed-level supersaturated design application to a robustness study on an organic synthesis
Alice Croguennoc, Marc Frédéric, Magalie Claeys-Bruno, Roger Phan-Tan-Luu, Michelle Sergent

01-Apr-2012 or purchase maybe required for full access)

A novel technique combining high-resolution synchrotron x-ray microtomography and x-ray diffraction for characterization of micro particulates
David R Merrifield1, Vasuki Ramachandran1, Kevin J Roberts1, Wesley Armour2, Danny Axford2, Mark Basham2, Thomas Connolley2, Gwyndaf Evans2, Katherine E McAuley2, Robin L Owen

01-Sep-2011 or purchase maybe required for full access)

Crystal Product Engineering in the Seeded Cooling Crystallization of Adipic Acid from Aqueous Solution
O. Narducci,† A. G. Jones,*,† and E. Kougoulos‡

01-Jul-2011 or purchase maybe required for full access)

Oligomerisation of linear 1-olefins using a chlorogallate(III) ionic liquid
Martin P. Atkins 1 , Kenneth R. Seddon 2 , and Małgorzata Swadźba-Kwaśny 2

01-Jun-2011 or purchase maybe required for full access)

The influence of reaction temperature on the oscillatory behaviour in the palladium-catalysed phenylacetylene oxidative carbonylation reaction
Katarina Novakovic,* Ankur Mukherjee, Mark Willis, Allen Wright and Steve Scott

01-Aug-2009 or purchase maybe required for full access)

Investigation of pH Effect on Hydrogenation Reaction of Dextrose to Sorbitol using a Mo promoted Sponge Ni catalyst
J. Matt Farmer*, Steven L. McMahon, and Bruce M. Lacey

01-Jun-2009 or purchase maybe required for full access)

Deactivation and regeneration of ruthenium on silica in the liquid-phase hydrogenation of butan-2-one
Haresh G. Manyar Daniel Weber Helen Daly Jillian M. Thompson David W. Rooney Lynn F. Gladden E. Hugh Stitt J. Jose Delgado Serafin Bernal Christopher Hardacre

01-May-2009 or purchase maybe required for full access)

Study of System Thermodynamics and the Feasibility of Chiral Resolution of the Polymorphic System of Malic Acid Enantiomers and Its Partial Solid Solutions
Henning Kaemmerer,*,† Heike Lorenz,‡ Simon N. Black,§ and Andreas Seidel-Morgenstern

01-Feb-2009 or purchase maybe required for full access)

Development of Scaffold Synthesis for the Preparation of New Insulin-Like Growth Factor 1 Receptor Inhibitors
Ilaria Candiani, Germano D’Arasmo,* Franco Heidempergher, and Attilio Tomasi

01-Jan-2009 or purchase maybe required for full access)

Polymorph and Particle Size Control of PPAR Compounds PF00287586 and AG035029
Billie J. Kline,* James Saenz, Nebojsˇa Stankovic ́, and Mark B. Mitchell

01-Mar-2006 or purchase maybe required for full access)

Thermal Hazards of the Vilsmeier−Haack Reaction on N,N-Dimethylaniline
Marcus Bollyn

03-Nov-2005 or purchase maybe required for full access)

Scale-Up of a Vilsmeier Formylation Reaction: Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory
Ulrich C. Dyer, David A. Henderson, Mark B. Mitchell, and Peter D. Tiffin

24-Apr-2002 or purchase maybe required for full access)

Scale-Up of a Vilsmeier Formylation Reaction:  Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory
Ulrich C. Dyer, David A. Henderson, Mark B. Mitchell, and Peter D. Tiffin

01-Apr-2002 or purchase maybe required for full access)

Determination of the onset of crystallization of N1-2-(thiazolyl) sulfanilamide (sulfathiazole) by UV-Vis and calorimetry using an automated reaction platform
Joanne E. Anderson, Shane Moore, Frank Tarczynski and Dwight Walker

01-Aug-2001 or purchase maybe required for full access)


The following are a list of available downloads.

Chemical Synthesis Specifications

Chemical Synthesis Brochure




start quote HEL has supplied us with high pressure reactors with automation which are working well and on the basis of this we are willing to recommend HEL for such systems. start quote

Watson Pharma – PVT

Fraunhofer-Institut für Chemische Technologie ICT

start quote We received the ordered parallel high pressure system, everything is working well. Training and instructions were good and we are very satisfied. start quote

Fraunhofer Institut Chemische Technologie – Germany

Queens University Belfast

start quote Three years ago we were developing a new catalytic process in collaboration with an industrial partner. It was essential to commission a reliable battery of glass reactors, built to our exact specification. We have decided to choose HEL’s AutoMATE II batch reactors array. We received professional advice, reactors built to specification, and a very thorough on-site training. The associated software is very intuitive and user-friendly. All issues occurring during the intensive use of the equipment were resolved quickly by the very helpful team at HEL. Last year, we have successfully progressed to a scale-up phase, for which we commissioned a custom-build AutoLAB reactor, with two exchangeable reaction vessels. Again, on all stages of ordering, manufacture and operation of the new reactor, the HEL staff were very helpful and made sure that their product was best suited to our needs. start quote

Belfast, Northern Ireland - Queen’s University

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