BioXplorer 400XL
Expanded Bench-Top, Parallel 8 Bioreactor Platform
Product Category: Bioprocess Development
Industry: Catalysis Chemical Synthesis and Crystallisation, Life Sciences, Pharmaceutical, Personal Care and Natural Products
Supplier: H.E.L. Group
Description
Featuring eight 500 ml bioreactors, the BioXplorer 400XL allows the fast optimization of critical parameters for aerobic fermentations. The parallel bioprocess capabilities of BioXplorer 400XL, combined with the customizable configuration of the bioreactor lid, unlocks the possibility of choosing what parameters to measure in real-time. Combined with the WinISO, the BioXplorer 400XL is able to respond to the change happening in the bioprocess, allowing for complete automatization of the fermentation.
Overview
Enhanced Bioreactor System
The BioXplorer 400XL has eight bioreactors, each optimized for aerobic fermentation and each allowing 120 mL – 400 mL working volume. These bioreactors can be equipped with a wide variety of probes and sensors, and the system offers multiple gas and liquid feed configurations. The ability to precisely control and monitor up to eight bioprocesses in parallel greatly accelerates screening and optimization studies, leading to more profound process knowledge and faster scale-up.
Flexibility and control
BioXplorer 400XL combines increased larger volumes with the replication and parallelization capabilities of having eight independent reactors controlled by WinISO. This software monitors the parameters of interest in the bioreactor and, at the same time, permits stringent control over them, always maintaining ideal conditions within the reactor. Combined with the ability to customize and the flexibility and variety of liquid and gas pumps and agitation, it results in great tools to characterize and optimize bioprocesses.
Features and Options
| Specification Point | BioXplorer 400XL |
|---|---|
| Number of independent parallel bioreactors | 8 |
| Bioreactor material | Glass body, stainless steel lid |
| Total volume | 500ml |
| Working volume | 120 – 400 ml |
| Sterilization | Autoclavable bioreactors (including sensors) |
| Temperature Range | 0 – 135°C |
| Temperature resolution | 0.1°C |
| Stirrer drive | Magnetically driven captive impeller or Overhead agitation (magnetically coupled) |
| Stirrer speed |
|
| Auto re-couple |
|
| Liquid additions with independent control for each bioreactor | Magnetically Driven – 2 as standard, options for up to 2 additional liquid feeds |
| Gas additions | 1 set of 8 mass flow controllers allowing independent control for each reactor as standard, option for 1 additional set |
| Standard options for MFC calibration | Air, oxygen as option |
| Gas spargers | 1 |
| Exhaust gas | Peltier cooled condenser |
| pH control | 1-way control (2-way control optional) |
| Polarographic DO sensing | Standard |
| DO control | Gas/liquid flow rate, stirrer speed (Optional) |
| BioVIS – Understand cell density trends without taking samples | Optional |
| Foam/Level detection | Optional |
| Control PC and software | Windows® PC with WinISO control software preinstalled:
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* Upper temperature limit for data acquisition from standard pH and DO probes is 60 ˚C and 40 ˚C, respectively. The lower temperature limit requires an integrated circulator option.