MP-SPR Navi™ 420A ILVES
Get up to speed with 4-channels!
MP-SPR Navi™ 420A ILVES is an ideal solution for molecular interaction studies when high throughput is needed. Minimal dead volume with 4 liquid channels makes the instrument optimal for small molecules and antibody interaction measurements.Product Category: SPR
Industry: Life Sciences
Supplier: Bionavis
Description
Features and benefits
- 4 fluidic channels for high throughput
- Automation of samples from 96 and 384 well plates allows for unattended runs
- Measurements of kinetic constants, concentration and competition analysis, affinity and EC50
- KineticTitration for faster interaction affinity and kinetic measurements
- Exceptionally wide angular range 40˚ – 78˚ enables measurements of small organic molecules and large proteins, but also metallic nanoparticles and live cells. Most importantly, it enables in-line bulk effect separation – PureKinetics™
- Two independent wavelength measurements from each fluidic channel, enabling the detection of thickness and refractive index or conformational changes
- Controlled buffer flow conditions with precise syringe pumps and integrated degasser
- Software switch for serial and individual injections
- Partial loop injections allowing minimized sample consumption
- Complete software package for convenient control of the instrument and easy analysis of the results. 420A ILVES instrument comes with both TraceDrawer™ for MP-SPR Navi™ and MP-SPR Navi™ LayerSolver software. LayerSolver is an advantageous software to determine thickness and RI from multiple wavelength measurements whereas Trace Drawer™ is a powerful software for the determination of affinity and kinetic constants
- MP-SPR Navi™ instruments utilize optical RI matching elastomer and therefore, sensors are very easy to exchange and remove for further analysis with other methods such as AFM or microscopy
Videos
Put yourself in the shoes of a scientist with our GoPro movie and see a short IgG experiment using MP-SPR Navi™ 420A ILVES!
The MP-SPR Navi instruments uniquely feature PureKinetics™, a function that allows in-line measurements of bulk and thus resulting in uncompromised pure binding data. 420A ILVES allows for faster measurements using KineticTitration function, where samples are introduced in series from low to high concentration.
Whitepapers
Please see the Bionavis website for a series of application notes
https://www.bionavis.com/en/publication_type/application-notes/
Accessories
Flow-cells
We offer a wide variety of flow-cells suitable for specific applications. All flow-cells can be easily exchanged by the user.
Our standard flow-cells are available in a variety of materials (PDMS, PEEK, Kalrez) depending on application such as kinetic studies or material characterization. Inlet diameter of the tubings and fluidic channel volume is optimized for each purpose.
Our special flow-cells enable the combination of MP-SPR measurements with electrochemistry or fluorescence and the measurement of live cells. All our flow-cells enable measurements in air and liquid and our special gas flow-cell enables even measurements with pressurized gas.
Contact us for more information and to find the most suitable flow-cell for your measurements!
MP-SPR Navi™ Immobilizer
Our MP-SPR Navi™ Immobilizer is an especially designed stand-alone holder for chemical modifications and functionalization of MP-SPR Navi™ sensor surfaces. MP-SPR Navi™ Immobilizer is compatible with the MP-SPR Navi™ sensor slides and MP-SPR Navi™ sensor slide holder.
Read more about immobilizer in AN#130.
Contact us for more information on our MP-SPR Navi™ immobilizer.
We provide the only MP-SPR instruments on the market that can be equipped with multiple wavelengths!
MP-SPR measures uniquely same surface spot at two different wavelengths which enables thickness and refractive index measurements. This feature is useful in all MP-SPR applications but especially with material characterization, biophysics, and live cell studies.
All MP-SPR Navi™ instruments can be equipped with up to 2 different wavelengths in each channel. MP-SPR Navi™ 200 OTSO, 210A VASA and 220A NAALI instruments can be equipped with up to 4 different wavelengths in each channel.
Additional wavelength option should be selected together with the instrument.
Get most out of the feature and combine it with LayerSolver software.
If you already have MP-SPR Navi™ system, contact us to learn how to upgrade it with additional lasers!
We offer a wide range of sensor slides manufactured according to high quality standards
All BioNavis sensors are cut to 12х20 mm size to fit into the BioNavis sensor slide holder and thus sensors are compatible with all the SPR Navi™ and MP-SPR Navi™ instruments.
Please see the Bionavis website for the range and choose the best sensor surface for your measurements. https://www.bionavis.com/en/products/additional-options-and-consumables/sensor-slides/
BioNavis offers a variety of software for data collection with our MP-SPR Navi™ instruments and analysis of MP-SPR data
https://www.bionavis.com/en/products/additional-options-and-consumables/software/